Anti-SPSB2 antibody (STJA0004709)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human SPSB2
General Information
| Short Description | Rabbit polyclonal anti-Spry Domain-Containing Socs Box Protein 2 for use in IHC and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1.2 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | IHC 1:50-1:100 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | SPSB2 |
| Gene ID | 84727 |
| Uniprot ID | SPSB2_HUMAN |
| Immunogen | Fusion protein of human SPSB2 |
Additional Info
| Function | Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5. |
| Protein Name | Spry Domain-Containing Socs Box Protein 2Ssb-2Gene-Rich Cluster Protein C9 |
| Database Links | Reactome: R-HSA-8951664Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmCytosolExhibits A Diffuse Cytosolic Localization |
| Alternative Antibody Names | Anti-Spry Domain-Containing Socs Box Protein 2 antibodyAnti-Ssb-2 antibodyAnti-Gene-Rich Cluster Protein C9 antibodyAnti-SPSB2 antibodyAnti-GRCC9 antibodyAnti-SSB2 antibody |
Information sourced from Uniprot.org