• Western blot analysis of various lysates using SPR Rabbit polyclonal antibody (STJ113293) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3s.

Anti-SPR antibody (1-261) (STJ113293)

SKU:
STJ113293

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SPR (1-261) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SPR
Gene ID: 6697
Uniprot ID: SPRE_HUMAN
Immunogen Region: 1-261
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-261 of human SPR (NP_003115.1).
Immunogen Sequence: MEGGLGRAVCLLTGASRGFG RTLAPLLASLLSPGSVLVLS ARNDEALRQLEAELGAERSG LRVVRVPADLGAEAGLQQLL GALRELPRPKGLQRLLLINN AGSLGDVSKGFVDLSDSTQV NNYWALNLTSMLCLTSSVLK AFPDSPGLNRTVVNISSLCA LQPFKGWALYCAGKAARDML FQVLALEEPNVRVLNYAPGP LDTDMQQLARETSVDPDMRK GLQELKAKGKLVDCKVSAQ
Post Translational Modifications In vitro phosphorylation of Ser-213 by CaMK2 does not change kinetic parameters.
Function Catalyzes the final one or two reductions in tetra-hydrobiopterin biosynthesis to form 5,6,7,8-tetrahydrobiopterin.
Protein Name Sepiapterin Reductase
Spr
Database Links Reactome: R-HSA-1474151
Reactome: R-HSA-203615
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Sepiapterin Reductase antibody
Anti-Spr antibody
Anti-SPR antibody

Information sourced from Uniprot.org

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