Anti-SPINK5 antibody (100-200) [S4112RM] (STJ11104112)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Serine Protease Inhibitor Kazal-Type 5 (100-200) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4112RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SPINK5 |
| Gene ID | 11005 |
| Uniprot ID | ISK5_HUMAN |
| Immunogen Region | 100-200 |
| Immunogen Sequence | FKKGERDGDFICPDYYEAVC GTDGKTYDNRCALCAENAKT GSQIGVKSEGECKSSNPEQD VCSAFRPFVRDGRLGCTREN DPVLGPDGKTHGNKCAMCAE L |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human SPINK5/LEKTI (Q9NQ38). |
Additional Info
| Tissue Specificity | Highly expressed in the thymus and stratum corneum. Also found in the oral mucosa, parathyroid gland, Bartholin's glands, tonsils, and vaginal epithelium. Very low levels are detected in lung, kidney, and prostate. |
| Post Translational Modifications | Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases. |
| Function | Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, it's major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. |
| Protein Name | Serine Protease Inhibitor Kazal-Type 5Lympho-Epithelial Kazal-Type-Related InhibitorLekti Cleaved Into - Hemofiltrate Peptide Hf6478 - Hemofiltrate Peptide Hf7665 |
| Database Links | Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Serine Protease Inhibitor Kazal-Type 5 antibodyAnti-Lympho-Epithelial Kazal-Type-Related Inhibitor antibodyAnti-Lekti Cleaved Into - Hemofiltrate Peptide Hf6478 - Hemofiltrate Peptide Hf7665 antibodyAnti-SPINK5 antibody |
Information sourced from Uniprot.org