| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPIB |
| Gene ID: | 6689 |
| Uniprot ID: | SPIB_HUMAN |
| Immunogen Region: | 1-262 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-262 of human SPIB (NP_003112.2). |
| Immunogen Sequence: | MLALEAAQLDGPHFSCLYPD GVFYDLDSCKHSSYPDSEGA PDSLWDWTVAPPVPATPYEA FDPAAAAFSHPQAAQLCYEP PTYSPAGNLELAPSLEAPGP GLPAYPTENFASQTLVPPAY APYPSPVLSEEEDLPLDSPA LEVSDSESDEALVAGPEGKG SEAGTRKKLRLYQFLLGLLT RGDMRECVWWVEPGAGVFQF SSKHKELLARRWGQQKGNRK RMTYQKLARALRNYAKTGE |
| Tissue Specificity | Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver. |
| Function | Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. |
| Protein Name | Transcription Factor Spi-B |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Transcription Factor Spi-B antibodyAnti-SPIB antibody |
Information sourced from Uniprot.org