| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SPIB (1-262) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SPIB |
| Gene ID: |
6689 |
| Uniprot ID: |
SPIB_HUMAN |
| Immunogen Region: |
1-262 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-262 of human SPIB (NP_003112.2). |
| Immunogen Sequence: |
MLALEAAQLDGPHFSCLYPD GVFYDLDSCKHSSYPDSEGA PDSLWDWTVAPPVPATPYEA FDPAAAAFSHPQAAQLCYEP PTYSPAGNLELAPSLEAPGP GLPAYPTENFASQTLVPPAY APYPSPVLSEEEDLPLDSPA LEVSDSESDEALVAGPEGKG SEAGTRKKLRLYQFLLGLLT RGDMRECVWWVEPGAGVFQF SSKHKELLARRWGQQKGNRK RMTYQKLARALRNYAKTGE |
| Tissue Specificity | Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver. |
| Function | Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. |
| Protein Name | Transcription Factor Spi-B |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Transcription Factor Spi-B antibodyAnti-SPIB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
