| Short Description : | Rabbit polyclonal anti-Transcription factor Spi-B for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SPIB |
| Gene ID: | 6689 |
| Uniprot ID: | SPIB_HUMAN |
| Immunogen: | Synthesized peptide derived from human SPIB |
| Specificity: | This antibody detects endogenous levels of SPIB at Human, Mouse, Rat |
| Function | Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. |
| Protein Name | Transcription Factor Spi-B |
| Database Links | |
| Cellular Localisation | Isoform 1: NucleusIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Transcription Factor Spi-B antibodyAnti-SPIB antibody |
Information sourced from Uniprot.org
