| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-SPEN/SHARP (Internal) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:4000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
SPEN |
| Gene ID: |
23013 |
| Uniprot ID: |
MINT_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_055816.2 |
| Immunogen Sequence: |
DSEGKMDDKKEDHKE |
| Function | May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. |
| Protein Name | Msx2-Interacting ProteinSmart/Hdac1-Associated Repressor ProteinSpen Homolog |
| Database Links | Reactome: R-HSA-9013422 |
| Cellular Localisation | NucleusAssociates With Chromatin |
| Alternative Antibody Names | Anti-Msx2-Interacting Protein antibodyAnti-Smart/Hdac1-Associated Repressor Protein antibodyAnti-Spen Homolog antibodyAnti-SPEN antibodyAnti-KIAA0929 antibodyAnti-MINT antibodyAnti-SHARP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
