Anti-SPCS1 antibody (STJA0007442)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SPCS1
General Information
| Short Description | Rabbit polyclonal anti-Signal peptidase complex subunit 1 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SPCS1 |
| Gene ID | 28972 |
| Uniprot ID | SPCS1_HUMAN |
| Immunogen | Synthesized peptide derived from human SPCS1 |
| Specificity | This antibody detects endogenous levels of SPCS1 at Human, Mouse |
Additional Info
| Function | Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity. (Microbial infection) Required for the post-translational processing of proteins involved in virion assembly and secretion from flaviviruses such as West Nile virus (WNV), Japanese encephalitis virus (JEV), Dengue virus type 2 (DENV-2), Yellow Fever virus (YFV), Zika virus (ZIKV) and hepatitis C virus (HCV). Plays a key role in the post-translational processing of flaviviral structural proteins prM, E, and NS1. In HCV, it is involved in virion assembly where it promotes the interaction between HCV virus proteins NS2 and E2. |
| Protein Name | Signal Peptidase Complex Subunit 1Microsomal Signal Peptidase 12 Kda SubunitSpase 12 Kda Subunit |
| Database Links | Reactome: R-HSA-1799339Reactome: R-HSA-381771Reactome: R-HSA-400511Reactome: R-HSA-422085Reactome: R-HSA-9828806 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Signal Peptidase Complex Subunit 1 antibodyAnti-Microsomal Signal Peptidase 12 Kda Subunit antibodyAnti-Spase 12 Kda Subunit antibodyAnti-SPCS1 antibodyAnti-SPC12 antibodyAnti-HSPC033 antibody |
Information sourced from Uniprot.org