Anti-SPATA13 antibody (STJA0008804)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SPATA13
General Information
| Short Description | Rabbit polyclonal anti-Spermatogenesis-associated protein 13 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SPATA13 |
| Gene ID | 221178 |
| Uniprot ID | SPT13_HUMAN |
| Immunogen | Synthesized peptide derived from human SPATA13 |
| Specificity | This antibody detects endogenous levels of SPATA13 at Human, Mouse |
Additional Info
| Function | Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. |
| Protein Name | Spermatogenesis-Associated Protein 13Apc-Stimulated Guanine Nucleotide Exchange Factor 2Asef2 |
| Database Links | Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCell ProjectionFilopodiumLamellipodiumRuffle MembranePodosomeAccumulates In The Lamellipodium And Ruffle Membrane In Response To Hepatocyte Growth Factor (Hgf) TreatmentLocalized To The Core Of Myotube Podosomes |
| Alternative Antibody Names | Anti-Spermatogenesis-Associated Protein 13 antibodyAnti-Apc-Stimulated Guanine Nucleotide Exchange Factor 2 antibodyAnti-Asef2 antibodyAnti-SPATA13 antibody |
Information sourced from Uniprot.org