![Anti-SP140 nanobody [SAA0901] (STJN000264)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200877/413059/STJN000264-SDS-PAGE-1__42885.1749232568.jpg?c=1 "Anti-SP140 nanobody [SAA0901] (STJN000264)")
![Anti-SP140 nanobody [SAA0901] (STJN000264)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200877/413059/STJN000264-SDS-PAGE-1__42885.1749232568.jpg?c=1 "Anti-SP140 nanobody [SAA0901] (STJN000264)")
Anti-SP140 nanobody [SAA0901] (STJN000264)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Nuclear Body Protein Sp140 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0901 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | SP140 |
| Gene ID | 11262 |
| Uniprot ID | SP140_HUMAN |
Additional Info
| Post Translational Modifications | Phosphorylation at Thr-726 promotes binding of PIN1 and subsequent isomerization of Pro-727. |
| Function | Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails. |
| Protein Name | Nuclear Body Protein Sp140Lymphoid-Restricted Homolog Of Sp100Lysp100Nuclear Autoantigen Sp-140Speckled 140 Kda |
| Database Links | |
| Cellular Localisation | NucleusPml BodyCytoplasmLocalized To Nuclear Structures Termed LandsFor Lysp100-Associated Nuclear DomainsLands Are GlobularElectron-Dense Structures Most Often Found In The NucleoplasmBut Also Found At The Nuclear Membrane And In The CytoplasmSuggesting That These Structures May Traffic Between The Cytoplasm And The NucleusAlso Colocalizes With Pml In A Subset Of Pml Nuclear Bodies |
| Alternative Nanobody Names | Anti-Nuclear Body Protein Sp140 nanobodyAnti-Lymphoid-Restricted Homolog Of Sp100 nanobodyAnti-Lysp100 nanobodyAnti-Nuclear Autoantigen Sp-140 nanobodyAnti-Speckled 140 Kda nanobodyAnti-SP140 nanobodyAnti-LYSP100 nanobody |
Information sourced from Uniprot.org