| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Mouse/Rat/Pig |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Sp1 (mouse)-Mouse (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-0.3-1µg/mlELISA-antibody detection limit dilution 1:8000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_038700.2 |
| Immunogen Sequence: |
DGIHDETAGGEGEN |
| Function | Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter Plays an essential role in the regulation of FE65 gene expression. Positively regulates the transcription of the core clock component ARNTL/BMAL1. Plays a role in protecting cells against oxidative stress following brain injury by regulating the expression of RNF112. |
| Protein Name | Transcription Factor Sp1Specificity Protein 1 |
| Database Links | Reactome: R-MMU-2173796Reactome: -MMU-6807505Reactome: -MMU-9018519 |
| Cellular Localisation | NucleusCytoplasmNuclear Location Is Governed By Glycosylated/Phosphorylated StatesInsulin Promotes Nuclear LocationWhile Glucagon Favors Cytoplasmic Location |
| Alternative Antibody Names | Anti-Transcription Factor Sp1 antibodyAnti-Specificity Protein 1 antibodyAnti-Sp1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
