Anti-SOX4 antibody (350-450) [S4822RM] (STJ11104822)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Transcription Factor Sox-4 (350-450) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4822RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:20000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SOX4 |
| Gene ID | 6659 |
| Uniprot ID | SOX4_HUMAN |
| Immunogen Region | 350-450 |
| Immunogen Sequence | AAGRSPADHRGYASLRAASP APSSAPSHASSSASSHSSSS SSSGSSSSDDEFEDDLLDLN PSSNFESMSLGSFSSSSALD RDLDFNFEPGSGSHFEFPDY C |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human SOX4 (NP_003098.1). |
Additional Info
| Tissue Specificity | Testis, brain, and heart. |
| Post Translational Modifications | Acetylation at Lys-95 by KAT5 promotes the transcription activator activity and is required during myoblast differentiation. Acetylation by KAT5 abolishes the interaction between SOX4 and HDAC1 and switches SOX4 into a transcriptional activator. |
| Function | Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif. Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression. Involved in skeletal myoblast differentiation by promoting gene expression of CALD1. |
| Protein Name | Transcription Factor Sox-4 |
| Database Links | Reactome: R-HSA-3769402 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Sox-4 antibodyAnti-SOX4 antibody |
Information sourced from Uniprot.org