Anti-SOX30 antibody (1-150) (STJ117993)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SOX30 (1-150) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Sox30 |
| Gene ID | 214105 |
| Uniprot ID | SOX30_MOUSE |
| Immunogen Region | 1-150 |
| Immunogen Sequence | MERARPEPPPPPPPPPRQPP RPTPPRPLRPAPPAQPVEAA TFRAAAAERSQSPSAQATAA MAAVASSCGEAAAAGAQAAG TRRLLQVKPEQVLLLPPGGP GVPPAPDEGAAAAAAAAAAA ASSAQARLLQLRPELLLLPP QSAADGGPCR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of mouse SOX30 (NP_775560.1). |
Additional Info
| Tissue Specificity | Expressed in the lung (at protein level). Expressed in testes (at protein level). Expressed in preleptotene spermatocytes, round spermatids, and elongated spermatids in the testis (at protein level). Expressed in pachytene spermatocytes during stages 3 to 8 of spermatogenesis (at protein level). Increased expression in diplotene spermatocytes at stage 9-11 and in metaphase spermatocytes or secondary spermatocytes at stage 12. Expressed in ovaries. |
| Function | Acts both as a transcriptional activator and a repressor. Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription. Required to activate the expression of postmeiotic genes involved in spermiogenesis. Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4. |
| Protein Name | Transcription Factor Sox-30 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmEnriched At The Chromocenter |
| Alternative Antibody Names | Anti-Transcription Factor Sox-30 antibodyAnti-Sox30 antibody |
Information sourced from Uniprot.org