Anti-SOX15 antibody (Internal) (STJ71392)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SOX15 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 24kDa band observed in Human Skeletal Muscle lysates (calculated MW of 25.3kDa according to NP_008873.1). Recommended concentration: 0.1-0.3µg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SOX15 |
| Gene ID | 6665 |
| Uniprot ID | SOX15_HUMAN |
| Accession Number | NP_008873.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | CSLPQSDPRLQGE |
Additional Info
| Function | Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence. Acts as a transcriptional activator and repressor. Binds synergistically with POU5F1 (OCT3/4) to gene promoters. Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation. Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG. Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity. Regulates transcription of HRC via binding to it proximal enhancer region. Involved in skeletal muscle regeneration. Also plays a role in the development of myogenic precursor cells. |
| Protein Name | Transcription Factor Sox-15Protein Sox-12Protein Sox-20Sry-Box Transcription Factor 15 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Sox-15 antibodyAnti-Protein Sox-12 antibodyAnti-Protein Sox-20 antibodyAnti-Sry-Box Transcription Factor 15 antibodyAnti-SOX15 antibodyAnti-SOX12 antibodyAnti-SOX20 antibodyAnti-SOX26 antibodyAnti-SOX27 antibody |
Information sourced from Uniprot.org