• Western blot analysis of extracts of various cell lines, using SOS1 antibody (STJ29900) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-SOS1 antibody (1034-1333) (STJ29900)

SKU:
STJ29900

£169.50 - £449.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SOS1 (1034-1333) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SOS1
Gene ID: 6654
Uniprot ID: SOS1_HUMAN
Immunogen Region: 1034-1333
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1034-1333 of human SOS1 (NP_005624.2).
Immunogen Sequence: PLKSPGVRPSNPRPGTMRHP TPLQQEPRKISYSRIPESET ESTASAPNSPRTPLTPPPAS GASSTTDVCSVFDSDHSSPF HSSNDTVFIQVTLPHGPRSA SVSSISLTKGTDEVPVPPPV PPRRRPESAPAESSPSKIMS KHLDSPPAIPPRQPTSKAYS PRYSISDRTSISDPPESPPL LPPREPVRTPDVFSSSPLHL QPPPLGKKSDHGNAFFPNSP SPFTPPPPQTPSPHGTRRH
Tissue Specificity Expressed in gingival tissues.
Post Translational Modifications Phosphorylation at Ser-1134 and Ser-1161 by RPS6KA3 create YWHAB and YWHAE binding sites and which contribute to the negative regulation of EGF-induced MAPK1/3 phosphorylation.
Function Promotes the exchange of Ras-bound GDP by GTP. Probably by promoting Ras activation, regulates phosphorylation of MAP kinase MAPK3 in response to EGF. Catalytic component of a trimeric complex that participates in transduction of signals from Ras to Rac by promoting the Rac-specific guanine nucleotide exchange factor (GEF) activity.
Protein Name Son Of Sevenless Homolog 1
Sos-1
Database Links Reactome: R-HSA-112412
Reactome: R-HSA-1236382
Reactome: R-HSA-1250196
Reactome: R-HSA-1250347
Reactome: R-HSA-1433557
Reactome: R-HSA-1433559
Reactome: R-HSA-167044
Reactome: R-HSA-179812
Reactome: R-HSA-180336
Reactome: R-HSA-186763
Reactome: R-HSA-193648
Reactome: R-HSA-1963640
Reactome: R-HSA-210993
Reactome: R-HSA-2179392
Reactome: R-HSA-2424491
Reactome: R-HSA-2428933
Reactome: R-HSA-2730905
Reactome: R-HSA-2871796
Reactome: R-HSA-2871809
Reactome: R-HSA-354194
Reactome: R-HSA-375165
Reactome: R-HSA-416482
Reactome: R-HSA-428540
Reactome: R-HSA-5637810
Reactome: R-HSA-5654688
Reactome: R-HSA-5654693
Reactome: R-HSA-5654699
Reactome: R-HSA-5654700
Reactome: R-HSA-5654704
Reactome: R-HSA-5654706
Reactome: R-HSA-5654712
Reactome: R-HSA-5654719
Reactome: R-HSA-5655253
Reactome: R-HSA-5655291
Reactome: R-HSA-5655302
Reactome: R-HSA-5655332
Reactome: R-HSA-5673001
Reactome: R-HSA-74749
Reactome: R-HSA-74751
Reactome: R-HSA-8851805
Reactome: R-HSA-8853659
Reactome: R-HSA-8983432
Reactome: R-HSA-9013149
Reactome: R-HSA-9026519
Reactome: R-HSA-9027284
Reactome: R-HSA-9028731
Reactome: R-HSA-9034864
Reactome: R-HSA-912526
Reactome: R-HSA-9607240
Reactome: R-HSA-9634285
Reactome: R-HSA-9664565
Reactome: R-HSA-9665348
Reactome: R-HSA-9665686
Reactome: R-HSA-9670439
Reactome: R-HSA-9673767
Reactome: R-HSA-9673770
Reactome: R-HSA-9679191
Reactome: R-HSA-9680350
Reactome: R-HSA-9703465
Reactome: R-HSA-9703648
Reactome: R-HSA-983695
Alternative Antibody Names Anti-Son Of Sevenless Homolog 1 antibody
Anti-Sos-1 antibody
Anti-SOS1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance