Anti-SORD antibody (145-300) (STJ25655)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SORD (145-300) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SORD |
| Gene ID | 6652 |
| Uniprot ID | DHSO_HUMAN |
| Immunogen Region | 145-300 |
| Immunogen Sequence | DNVTFEEGALIEPLSVGIHA CRRGGVTLGHKVLVCGAGPI GMVTLLVAKAMGAAQVVVTD LSATRLSKAKEIGADLVLQI SKESPQEIARKVEGQLGCKP EVTIECTGAEASIQAGIYAT RSGGNLVLVGLGSEMTTVPL LHAAIREVDIKGVFRY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 145-300 of human Sorbitol Dehydrogenase (NP_003095.2). |
Additional Info
| Tissue Specificity | Expressed in liver. Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level). |
| Function | Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility. May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor. |
| Protein Name | Sorbitol DehydrogenaseSdh(R -R-Butanediol DehydrogenaseL-Iditol 2-DehydrogenasePolyol DehydrogenaseRibitol DehydrogenaseRdhXylitol DehydrogenaseXdh |
| Database Links | Reactome: R-HSA-5652227Reactome: R-HSA-5661270 |
| Cellular Localisation | Mitochondrion MembranePeripheral Membrane ProteinCell ProjectionCiliumFlagellumAssociated With Mitochondria Of The Midpiece And Near The Plasma Membrane In The Principal Piece Of The FlagellumAlso Found In The EpididymosomeSecreted By The Epididymal Epithelium And That Transfers Proteins From The Epididymal Fluid To The Sperm Surface |
| Alternative Antibody Names | Anti-Sorbitol Dehydrogenase antibodyAnti-Sdh antibodyAnti-(R -R-Butanediol Dehydrogenase antibodyAnti-L-Iditol 2-Dehydrogenase antibodyAnti-Polyol Dehydrogenase antibodyAnti-Ribitol Dehydrogenase antibodyAnti-Rdh antibodyAnti-Xylitol Dehydrogenase antibodyAnti-Xdh antibodyAnti-SORD antibody |
Information sourced from Uniprot.org