| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SORD (145-300) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SORD |
| Gene ID: |
6652 |
| Uniprot ID: |
DHSO_HUMAN |
| Immunogen Region: |
145-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 145-300 of human Sorbitol Dehydrogenase (NP_003095.2). |
| Immunogen Sequence: |
DNVTFEEGALIEPLSVGIHA CRRGGVTLGHKVLVCGAGPI GMVTLLVAKAMGAAQVVVTD LSATRLSKAKEIGADLVLQI SKESPQEIARKVEGQLGCKP EVTIECTGAEASIQAGIYAT RSGGNLVLVGLGSEMTTVPL LHAAIREVDIKGVFRY |
| Tissue Specificity | Expressed in liver. Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level). |
| Function | Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility. May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor. |
| Protein Name | Sorbitol DehydrogenaseSdh(R -R-Butanediol DehydrogenaseL-Iditol 2-DehydrogenasePolyol DehydrogenaseRibitol DehydrogenaseRdhXylitol DehydrogenaseXdh |
| Database Links | Reactome: R-HSA-5652227Reactome: R-HSA-5661270 |
| Cellular Localisation | Mitochondrion MembranePeripheral Membrane ProteinCell ProjectionCiliumFlagellumAssociated With Mitochondria Of The Midpiece And Near The Plasma Membrane In The Principal Piece Of The FlagellumAlso Found In The EpididymosomeSecreted By The Epididymal Epithelium And That Transfers Proteins From The Epididymal Fluid To The Sperm Surface |
| Alternative Antibody Names | Anti-Sorbitol Dehydrogenase antibodyAnti-Sdh antibodyAnti-(R -R-Butanediol Dehydrogenase antibodyAnti-L-Iditol 2-Dehydrogenase antibodyAnti-Polyol Dehydrogenase antibodyAnti-Ribitol Dehydrogenase antibodyAnti-Rdh antibodyAnti-Xylitol Dehydrogenase antibodyAnti-Xdh antibodyAnti-SORD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
