| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Rat/Dog |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Sorbitol Dehydrogenase (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 38kDa band observed in Mouse Kidney lysates (calculated MW of 38.3kDa according to NP_003095.1). Recommended concentration: 0.1-0.3µg/ml. A minor band of unknown identity was al |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
SORD |
| Gene ID: |
6652 |
| Uniprot ID: |
DHSO_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_003095.2 |
| Immunogen Sequence: |
KIMLKCDPSDQNP |
| Function | Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility. May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor. |
| Protein Name | Sorbitol DehydrogenaseSdh(R -R-Butanediol DehydrogenaseL-Iditol 2-DehydrogenasePolyol DehydrogenaseRibitol DehydrogenaseRdhXylitol DehydrogenaseXdh |
| Database Links | Reactome: R-HSA-5652227Reactome: R-HSA-5661270 |
| Cellular Localisation | Mitochondrion MembranePeripheral Membrane ProteinCell ProjectionCiliumFlagellumAssociated With Mitochondria Of The Midpiece And Near The Plasma Membrane In The Principal Piece Of The FlagellumAlso Found In The EpididymosomeSecreted By The Epididymal Epithelium And That Transfers Proteins From The Epididymal Fluid To The Sperm Surface |
| Alternative Antibody Names | Anti-Sorbitol Dehydrogenase antibodyAnti-Sdh antibodyAnti-(R -R-Butanediol Dehydrogenase antibodyAnti-L-Iditol 2-Dehydrogenase antibodyAnti-Polyol Dehydrogenase antibodyAnti-Ribitol Dehydrogenase antibodyAnti-Rdh antibodyAnti-Xylitol Dehydrogenase antibodyAnti-Xdh antibodyAnti-SORD antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
