| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SON (850-950) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SON |
| Gene ID: |
6651 |
| Uniprot ID: |
SON_HUMAN |
| Immunogen Region: |
850-950 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 850-950 of human SON (NP_001278340.1). |
| Immunogen Sequence: |
TMDSQMLATSSMDSQMLASG TMDSQMLASGTMDAQMLASG TMDAQMLASSTQDSAMLGSK SPDPYRLAQDPYRLAQDPYR LGHDPYRLGHDAYRLGQDPY R |
| Tissue Specificity | Widely expressed, with the higher expression seen in leukocyte and heart. |
| Function | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA.binds to the consensus DNA sequence: 5'-GAGTANCGAGCC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1. |
| Protein Name | Protein SonBax Antagonist Selected In Saccharomyces 1Bass1Negative Regulatory Element-Binding ProteinNre-Binding ProteinProtein Dbp-5Son3 |
| Cellular Localisation | Nucleus SpeckleColocalizes With The Pre-Mrna Splicing Factor Srsf2 |
| Alternative Antibody Names | Anti-Protein Son antibodyAnti-Bax Antagonist Selected In Saccharomyces 1 antibodyAnti-Bass1 antibodyAnti-Negative Regulatory Element-Binding Protein antibodyAnti-Nre-Binding Protein antibodyAnti-Protein Dbp-5 antibodyAnti-Son3 antibodyAnti-SON antibodyAnti-C21orf50 antibodyAnti-DBP5 antibodyAnti-KIAA1019 antibodyAnti-NREBP antibodyAnti-HSPC310 antibodyAnti-HSPC312 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
