Anti-Somatostatin proprotein antibody (58-70) (STJ73652)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-Somatostatin proprotein (58-70) is suitable for use in ELISA, Immunofluorescence and Immunocytochemistry research applications. |
| Applications | Pep-ELISA/IF/ICC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:1000.Immunofluorescence/Immunocytochemistry: Strong expression of the protein seen in the plasma membrane and endoplasmic reticulum of U2OS and U251 cells. Recommended concentra |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SST |
| Gene ID | 6750 |
| Uniprot ID | SMS_HUMAN |
| Accession Number | NP_001039.1 |
| Immunogen Region | 58-70 |
| Immunogen Sequence | SEPNQTENDALEP |
Additional Info
| Function | Somatostatin-14: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH.the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. Neuronostatin: May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation. May regulate cardiac contractile function. May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation. May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH. |
| Protein Name | SomatostatinGrowth Hormone Release-Inhibiting Factor Cleaved Into - Somatostatin-28 - Somatostatin-14Sst-14 - NeuronostatinNst |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-9022702 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Somatostatin antibodyAnti-Growth Hormone Release-Inhibiting Factor Cleaved Into - Somatostatin-28 - Somatostatin-14 antibodyAnti-Sst-14 - Neuronostatin antibodyAnti-Nst antibodyAnti-SST antibody |
Information sourced from Uniprot.org