Anti-Somatostatin antibody [2G2-1B5-10A3] (STJA0033535)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Somatostatin
General Information
| Short Description | Mouse monoclonal anti-Somatostatin for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2G2-1B5-10A3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:100-1:500 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SST |
| Gene ID | 6750 |
| Uniprot ID | SMS_HUMAN |
| Immunogen | Synthesized peptide derived from human Somatostatin |
Additional Info
| Post Translational Modifications | C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure. |
| Function | Somatostatin-14: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH.the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. Neuronostatin: May enhance low-glucose-induced glucagon release by pancreatic alpha cells. This effect may be mediated by binding to GPR107 and PKA activation. May regulate cardiac contractile function. May compromise cardiomyocyte viability. In the central nervous system, may impair memory retention and may affect hippocampal excitability. May also have anxiolytic and anorexigenic effects. May play a role in arterial pressure regulation. May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH. Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH. |
| Protein Name | SomatostatinGrowth Hormone Release-Inhibiting Factor Cleaved Into - Somatostatin-28 - Somatostatin-14Sst-14 - NeuronostatinNst |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-9022702 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Somatostatin antibodyAnti-Growth Hormone Release-Inhibiting Factor Cleaved Into - Somatostatin-28 - Somatostatin-14 antibodyAnti-Sst-14 - Neuronostatin antibodyAnti-Nst antibodyAnti-SST antibody |
Information sourced from Uniprot.org