| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Suppressor of cytokine signaling 7 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SOCS7 |
| Gene ID: |
30837 |
| Uniprot ID: |
SOCS7_HUMAN |
| Specificity: |
SOCS7 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 7Socs-7Nck - Ash And Phospholipase C Gamma-Binding ProteinNck-Associated Protein 4Nap-4 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCytoplasmic SideNucleusMostly CytoplasmicBut Shuttles Between The Cytoplasm And The NucleusRapidly Relocalizes To The Nucleus After Uv IrradiationCytoplasmic Location Depends Upon Sept7 Presence |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 7 antibodyAnti-Socs-7 antibodyAnti-Nck - Ash And Phospholipase C Gamma-Binding Protein antibodyAnti-Nck-Associated Protein 4 antibodyAnti-Nap-4 antibodyAnti-SOCS7 antibodyAnti-NAP4 antibodyAnti-SOCS6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
