Anti-SOCS5 antibody (STJ191478)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Suppressor of cytokine signaling 5 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SOCS5 |
| Gene ID | 9655 |
| Uniprot ID | SOCS5_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SOCS5 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. |
| Protein Name | Suppressor Of Cytokine Signaling 5Socs-5Cytokine-Inducible Sh2 Protein 6Cis-6Cytokine-Inducible Sh2-Containing Protein 5 |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-8951664 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 5 antibodyAnti-Socs-5 antibodyAnti-Cytokine-Inducible Sh2 Protein 6 antibodyAnti-Cis-6 antibodyAnti-Cytokine-Inducible Sh2-Containing Protein 5 antibodyAnti-SOCS5 antibodyAnti-CIS6 antibodyAnti-CISH5 antibodyAnti-CISH6 antibodyAnti-KIAA0671 antibody |
Information sourced from Uniprot.org