• Biotinylated STJ70014 (1µg/ml) staining of Mouse Spleen lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocker as a substitute for skimmed milk.

Anti-SOCS1, biotinylated antibody (C-Term) {Biotin} (STJ73272)

SKU:
STJ73272-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-SOCS1, biotinylated (C-Term) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-3µg/ml
ELISA-antibody detection limit dilution 1:32000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SOCS1
Gene ID: 8651
Uniprot ID: SOCS1_HUMAN
Immunogen Region: C-Term
Accession Number: NP_003736.1
Immunogen Sequence: VLRDYLSSFPFQI.
Function Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
Protein Name Suppressor Of Cytokine Signaling 1
Socs-1
Jak-Binding Protein
Jab
Stat-Induced Stat Inhibitor 1
Ssi-1
Tec-Interacting Protein 3
Tip-3
Database Links Reactome: R-HSA-1266695
Reactome: R-HSA-1433559
Reactome: R-HSA-166058
Reactome: R-HSA-6785807
Reactome: R-HSA-877300
Reactome: R-HSA-877312
Reactome: R-HSA-909733
Reactome: R-HSA-912694
Reactome: R-HSA-9674555
Reactome: R-HSA-9705462
Reactome: R-HSA-982772
Reactome: R-HSA-983168
Cellular Localisation Nucleus
Cytoplasmic Vesicle
Detected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3
Alternative Antibody Names Anti-Suppressor Of Cytokine Signaling 1 antibody
Anti-Socs-1 antibody
Anti-Jak-Binding Protein antibody
Anti-Jab antibody
Anti-Stat-Induced Stat Inhibitor 1 antibody
Anti-Ssi-1 antibody
Anti-Tec-Interacting Protein 3 antibody
Anti-Tip-3 antibody
Anti-SOCS1 antibody
Anti-SSI1 antibody
Anti-TIP3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance