Anti-SOCS1 antibody (1-100 aa) [SRM5349] (STJ11107258)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal SOCS1 (1-100 aa) antibody for use in IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5349 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | IHC-P:1:100-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SOCS1 |
| Gene ID | 8651 |
| Uniprot ID | SOCS1_HUMAN |
| Immunogen Region | 1-100 aa |
| Immunogen Sequence | MVAHNQVAADNAVSTAAEPR RRPEPSSSSSSSPAAPARPR PCPAVPAPAPGDTHFRTFRS HADYRRITRASALLDACGFY WGPLSVHGAHERLRAEPVGT |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOCS1 (NP_003736.1). |
Additional Info
| Tissue Specificity | Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes. |
| Function | Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 1Socs-1Jak-Binding ProteinJabStat-Induced Stat Inhibitor 1Ssi-1Tec-Interacting Protein 3Tip-3 |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-1433559Reactome: R-HSA-166058Reactome: R-HSA-6785807Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-9674555Reactome: R-HSA-9705462Reactome: R-HSA-982772Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasmic VesicleDetected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3 |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 1 antibodyAnti-Socs-1 antibodyAnti-Jak-Binding Protein antibodyAnti-Jab antibodyAnti-Stat-Induced Stat Inhibitor 1 antibodyAnti-Ssi-1 antibodyAnti-Tec-Interacting Protein 3 antibodyAnti-Tip-3 antibodyAnti-SOCS1 antibodyAnti-SSI1 antibodyAnti-TIP3 antibody |
Information sourced from Uniprot.org