Anti-SNX27 antibody (STJA0009783)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SNX27
General Information
| Short Description | Rabbit polyclonal anti-Sorting nexin-27 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNX27 |
| Gene ID | 81609 |
| Uniprot ID | SNX27_HUMAN |
| Immunogen | Synthesized peptide derived from human SNX27 |
| Specificity | This antibody detects endogenous levels of SNX27 at Human, Mouse, Rat |
Additional Info
| Function | Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. |
| Protein Name | Sorting Nexin-27 |
| Database Links | |
| Cellular Localisation | Early Endosome MembranePeripheral Membrane ProteinCytoplasmCytosolLocalizes To Immunological Synapse In T-CellsIn T-CellsRecruited From The Cytosol To Sorting Endosomes By Phosphoinositide-3-Kinase Products |
| Alternative Antibody Names | Anti-Sorting Nexin-27 antibodyAnti-SNX27 antibodyAnti-KIAA0488 antibodyAnti-My014 antibody |
Information sourced from Uniprot.org