Anti-SNX2 antibody (STJA0004331)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human SNX2
General Information
| Short Description | Rabbit polyclonal anti-Sorting Nexin-2 for use in WB, IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.9 mg/mL |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000, IHC 1:25-1:100 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | SNX2 |
| Gene ID | 6643 |
| Uniprot ID | SNX2_HUMAN |
| Immunogen | Synthetic peptide of human SNX2 |
Additional Info
| Function | Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Required for retrograde endosome-to-TGN transport of TGN38. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation.the function is dependent on GEF activity of KALRN. |
| Protein Name | Sorting Nexin-2Transformation-Related Gene 9 ProteinTrg-9 |
| Database Links | Reactome: R-HSA-432722 |
| Cellular Localisation | Early Endosome MembranePeripheral Membrane ProteinCytoplasmic SideCell ProjectionLamellipodiumColocalized With Sort1 To Tubular Endosomal Membrane Structures Called Endosome-To-Tgn Transport Carriers (Etcs) Which Are Budding From Early Endosome Vacuoles Just Before Maturing Into Late Endosome VacuolesColocalized With F-Actin At The Leading Edge Of Lamellipodia In Cells In A Kalrn-Dependent Manner |
| Alternative Antibody Names | Anti-Sorting Nexin-2 antibodyAnti-Transformation-Related Gene 9 Protein antibodyAnti-Trg-9 antibodyAnti-SNX2 antibodyAnti-TRG9 antibody |
Information sourced from Uniprot.org