Anti-SNRPD3 antibody (8-121) (STJ118510)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SNRPD3 (8-121) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNRPD3 |
| Gene ID | 6634 |
| Uniprot ID | SMD3_HUMAN |
| Immunogen Region | 8-121 |
| Immunogen Sequence | KVLHEAEGHIVTCETNTGEV YRGKLIEAEDNMNCQMSNIT VTYRDGRVAQLEQVYIRGSK IRFLILPDMLKNAPMLKSMK NKNQGSGAGRGKAAILKAQV AARGRGRGMGRGNI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 8-121 of human SNRPD3 (NP_001265585). |
Additional Info
| Post Translational Modifications | Methylated on arginine residues by PRMT5 and PRMT7.probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs. |
| Function | Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. |
| Protein Name | Small Nuclear Ribonucleoprotein Sm D3Sm-D3Snrnp Core Protein D3 |
| Database Links | Reactome: R-HSA-111367Reactome: R-HSA-191859Reactome: R-HSA-72163Reactome: R-HSA-72165Reactome: R-HSA-73856Reactome: R-HSA-77588Reactome: R-HSA-9754678 |
| Cellular Localisation | CytoplasmCytosolNucleusSmn-Mediated Assembly Into Core Snrnps Occurs In The Cytosol Before Smn-Mediated Transport To The Nucleus To Be Included In Spliceosomes |
| Alternative Antibody Names | Anti-Small Nuclear Ribonucleoprotein Sm D3 antibodyAnti-Sm-D3 antibodyAnti-Snrnp Core Protein D3 antibodyAnti-SNRPD3 antibody |
Information sourced from Uniprot.org