| Short Description : | Rabbit polyclonal SNRNP200 (1947-2136) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SNRNP200 |
| Gene ID: | 23020 |
| Uniprot ID: | U520_HUMAN |
| Immunogen Region: | 1947-2136 |
| Immunogen Sequence: | QMVTQAMWSKDSYLKQLPHF TSEHIKRCTDKGVESVFDIM EMEDEERNALLQLTDSQIAD VARFCNRYPNIELSYEVVDK DSIRSGGPVVVLVQLEREEE VTGPVIAPLFPQKREEGWWV VIGDAKSNSLISIKRLTLQQ KAKVKLDFVAPATGAHNYTL YFMSDAYMGCDQEYKFSVDV KEAETDSDSD |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1947-2136 of human SNRNP200 (NP_054733.2). |
| Tissue Specificity | Widely expressed. |
| Function | Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome. Plays a role in pre-mRNA splicing as a core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. |
| Protein Name | U5 Small Nuclear Ribonucleoprotein 200 Kda HelicaseActivating Signal Cointegrator 1 Complex Subunit 3-Like 1Brr2 HomologU5 Snrnp-Specific 200 Kda ProteinU5-200kd |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72165 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-U5 Small Nuclear Ribonucleoprotein 200 Kda Helicase antibodyAnti-Activating Signal Cointegrator 1 Complex Subunit 3-Like 1 antibodyAnti-Brr2 Homolog antibodyAnti-U5 Snrnp-Specific 200 Kda Protein antibodyAnti-U5-200kd antibodyAnti-SNRNP200 antibodyAnti-ASCC3L1 antibodyAnti-BRR2 antibodyAnti-HELIC2 antibodyAnti-KIAA0788 antibody |
Information sourced from Uniprot.org
