Anti-SNM1 antibody (C-Term) (STJ70542)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SNM1 (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Preliminary experiments gave no signal but low background in Human Brain and Testis lysates at up to 1µg/ml (note whole-cell RIPA lysates not nuclear lysates).IHC: Paraffin embedd |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | DCLRE1A |
| Gene ID | 9937 |
| Uniprot ID | DCR1A_HUMAN |
| Accession Number | NP_055696.3 |
| Immunogen Region | C-Term |
| Immunogen Sequence | EKYFREWKLEAGY |
Additional Info
| Function | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem). |
| Protein Name | Dna Cross-Link Repair 1a ProteinBeta-Lactamase Dclre1aSnm1 Homolog AHsnm1Hsnm1a |
| Database Links | Reactome: R-HSA-6783310 |
| Cellular Localisation | NucleusIn Some Cells It May Be Found In Typically 1 Or 2 Discrete Nuclear Aggregates Of Unknown Function Which Also Contain Tp53bp1Also Found In Multiple Discrete Nuclear Foci Which Increase In Number Following Treatment With Ionizing Radiation Or Interstrand Cross-Linking AgentsThese Foci Overlap With Those Formed By The Mrn Complex (Composed Of Mre11Rad50 And Nbn) And Brca1 |
| Alternative Antibody Names | Anti-Dna Cross-Link Repair 1a Protein antibodyAnti-Beta-Lactamase Dclre1a antibodyAnti-Snm1 Homolog A antibodyAnti-Hsnm1 antibodyAnti-Hsnm1a antibodyAnti-DCLRE1A antibodyAnti-KIAA0086 antibodyAnti-SNM1 antibodyAnti-SNM1A antibody |
Information sourced from Uniprot.org