Anti-SNIP1 antibody (200-300) (STJ119155)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SNIP1 (200-300) antibody for use in WB, IHC-P, IF, ICC and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SNIP1 |
| Gene ID | 79753 |
| Uniprot ID | SNIP1_HUMAN |
| Immunogen Region | 200-300 |
| Immunogen Sequence | SESQELVPRPGGNNKEKEVP AKEKPSFELSGALLEDTNTF RGVVIKYSEPPEARIPKKRW RLYPFKNDEVLPVMYIHRQS AYLLGRHRRIADIPIDHPSC S |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human SNIP1 (NP_078976.2). |
Additional Info
| Tissue Specificity | Ubiquitous, with highest expression in heart and skeletal muscle. |
| Post Translational Modifications | Degraded by the proteasome upon binding to the SMAD1/OAZ1/PSMB4 complex. |
| Function | Required for pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. |
| Protein Name | Smad Nuclear-Interacting Protein 1Fha Domain-Containing Protein Snip1 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Smad Nuclear-Interacting Protein 1 antibodyAnti-Fha Domain-Containing Protein Snip1 antibodyAnti-SNIP1 antibody |
Information sourced from Uniprot.org