Anti-SNF8 antibody (200-250) {Biotin} (STJ503495)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 200-250 on human Vacuolar-sorting Protein SNF8 protein.
General Information
| Short Description | Rabbit polyclonal antibody anti-SNF8 (200-250) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.5-1.5 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:2, 500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | SNF8 |
| Gene ID | 11267 |
| Uniprot ID | SNF8_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 200-250 on human Vacuolar-sorting Protein SNF8 protein. |
| Immunogen Region | 200-250 |
Additional Info
| Function | Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs, and plays a role in autophagy. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. It is also required for the degradation of CXCR4. Required for the exosomal release of SDCBP, CD63 and syndecan. |
| Protein Name | Vacuolar-Sorting Protein Snf8Ell-Associated Protein Of 30 KdaEscrt-Ii Complex Subunit Vps22Hvps22 |
| Database Links | Reactome: R-HSA-917729Reactome: R-HSA-9610379 |
| Cellular Localisation | CytoplasmEndosome MembraneNucleusLate Endosome MembraneRecruited To The Endosome Membrane To Participate In Vesicle Formation |
| Alternative Antibody Names | Anti-Vacuolar-Sorting Protein Snf8 antibodyAnti-Ell-Associated Protein Of 30 Kda antibodyAnti-Escrt-Ii Complex Subunit Vps22 antibodyAnti-Hvps22 antibodyAnti-SNF8 antibodyAnti-EAP30 antibody |
Information sourced from Uniprot.org