![Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/101484/389297/STJ28147_IHC_3__60225.1713158958.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
![Immunohistochemistry analysis of paraffin-embedded mouse kidney using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/101484/389298/STJ28147_IHC_4__18105.1713158959.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded mouse kidney using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
![Immunohistochemistry analysis of paraffin-embedded rat colon using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/101484/389299/STJ28147_IHC_5__64932.1713158959.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded rat colon using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
![Immunohistochemistry analysis of paraffin-embedded rat kidney using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/101484/389300/STJ28147_IHC_6__32693.1713158960.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded rat kidney using [KO Validated] SND1 rabbit polyclonal antibody (STJ28147) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
| Short Description : | Rabbit polyclonal SND1 (26-285) antibody for use in WB, IHC-P, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/IF/ICC/IP/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specif |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SND1 |
| Gene ID: | 27044 |
| Uniprot ID: | SND1_HUMAN |
| Immunogen Region: | 26-285 |
| Immunogen Sequence: | MVLSGCAIIVRGQPRGGPPP ERQINLSNIRAGNLARRAAA TQPDAKDTPDEPWAFPAREF LRKKLIGKEVCFTIENKTPQ GREYGMIYLGKDTNGENIAE SLVAEGLATRREGMRANNPE QNRLSECEEQAKAAKKGMWS EGNGSHTIRDLKYTIENPRH FVDSHHQKPVNAIIEHVRDG SVVRALLLPDYYLVTVMLSG IKCPTFRREADGSETPEPFA AEAKFFTESRLLQRDVQII |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-285 of human SND1 (NP_055205.2). |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated by PIM1 in vitro. |
| Function | Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. As part of its function in miRNA decay, regulates mRNAs involved in G1-to-S phase transition. Functions as a bridging factor between STAT6 and the basal transcription factor. Plays a role in PIM1 regulation of MYB activity. Functions as a transcriptional coactivator for STAT5. (Microbial infection) Functions as a transcriptional coactivator for the Epstein-Barr virus nuclear antigen 2 (EBNA2). (Microbial infection) Promotes SARS-CoV-2 RNA synthesis by binding to negative-sense RNA and the viral protein nsp9. |
| Protein Name | Staphylococcal Nuclease Domain-Containing Protein 1100 Kda CoactivatorEbna2 Coactivator P100Tudor Domain-Containing Protein 11P100 Co-Activator |
| Database Links | Reactome: R-HSA-6802952 |
| Cellular Localisation | CytoplasmNucleusMelanosomeIn Il-4 Stimulated Cells Colocalizes With Stat6 In The NucleusIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Staphylococcal Nuclease Domain-Containing Protein 1 antibodyAnti-100 Kda Coactivator antibodyAnti-Ebna2 Coactivator P100 antibodyAnti-Tudor Domain-Containing Protein 11 antibodyAnti-P100 Co-Activator antibodyAnti-SND1 antibodyAnti-TDRD11 antibody |
Information sourced from Uniprot.org
