Anti-SNCB antibody (80 aa C-Term) (STJ140169)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant peptide derived from within residues 80 aa to the C-terminus of human SNCB produced in E. coli.
General Information
| Short Description | Goat polyclonal SNCB (80 aa C-Term) antibody for use in WB in human, rat, mouse, canine and monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Goat |
| Reactivity | Human/Rat/Mouse/Canine/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 2 mg/mL |
| Purification | Epitope affinity purified |
| Dilution Range | WB 1:500-1:5000 |
| Formulation | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Storage Instruction | For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
Target Information
| Gene Symbol | SNCB |
| Gene ID | 6620 |
| Uniprot ID | SYUB_HUMAN |
| Immunogen | Recombinant peptide derived from within residues 80 aa to the C-terminus of human SNCB produced in E. coli. |
| Immunogen Region | 80 aa C-Term |
| Immunogen Sequence | SRETGLVKREEFPTDLKPEE RETGLVKREEFPTDLKPEEV ETGLVKREEFPTDLKPEEVA |
| Specificity | Detects endogenous levels of SNCB by Western blot. This Ab is specific for SNCB and does not recognizes SNCA and SNCG proteins. |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II. |
| Function | Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease. |
| Protein Name | Beta-Synuclein |
| Database Links | Reactome: R-HSA-5660489 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Beta-Synuclein antibodyAnti-SNCB antibody |
Information sourced from Uniprot.org