Anti-SMPDL3B antibody (STJA0007489)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SMPDL3B
General Information
| Short Description | Rabbit polyclonal anti-Acid sphingomyelinase-like phosphodiesterase 3b for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SMPDL3B |
| Gene ID | 27293 |
| Uniprot ID | ASM3B_HUMAN |
| Immunogen | Synthesized peptide derived from human SMPDL3B |
| Specificity | This antibody detects endogenous levels of SMPDL3B at Human, Mouse |
Additional Info
| Function | Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro). |
| Protein Name | Acid Sphingomyelinase-Like Phosphodiesterase 3bAsm-Like Phosphodiesterase 3b |
| Database Links | |
| Cellular Localisation | SecretedCell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Acid Sphingomyelinase-Like Phosphodiesterase 3b antibodyAnti-Asm-Like Phosphodiesterase 3b antibodyAnti-SMPDL3B antibodyAnti-ASML3B antibodyAnti-ASMLPD antibody |
Information sourced from Uniprot.org