Anti-SMG8 antibody (STJA0004612)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human SMG8
General Information
| Short Description | Rabbit polyclonal anti-Nonsense-Mediated Mrna Decay Factor Smg8 for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity purification |
| Dilution Range | IHC 1:25-1:100 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | SMG8 |
| Gene ID | 55181 |
| Uniprot ID | SMG8_HUMAN |
| Immunogen | Synthetic peptide of human SMG8 |
Additional Info
| Post Translational Modifications | Phosphorylated by SMG1. |
| Function | Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity. |
| Protein Name | Nonsense-Mediated Mrna Decay Factor Smg8Amplified In Breast Cancer Gene 2 ProteinProtein Smg-8 Homolog |
| Database Links | Reactome: R-HSA-975957 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Nonsense-Mediated Mrna Decay Factor Smg8 antibodyAnti-Amplified In Breast Cancer Gene 2 Protein antibodyAnti-Protein Smg-8 Homolog antibodyAnti-SMG8 antibodyAnti-ABC2 antibodyAnti-C17orf71 antibody |
Information sourced from Uniprot.org