Anti-SMG7 antibody (1-300) (STJ117566)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SMG7 (1-300) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SMG7 |
| Gene ID | 9887 |
| Uniprot ID | SMG7_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MSLQSAQYLRQAEVLKADMT DSKLGPAEVWTSRQALQDLY QKMLVTDLEYALDKKVEQDL WNHAFKNQITTLQGQAKNRA NPNRSEVQANLSLFLEAASG FYTQLLQELCTVFNVDLPCR VKSSQLGIISNKQTHTSAIV KPQSSSCSYICQHCLVHLGD IARYRNQTSQAESYYRHAAQ LVPSNGQPYNQLAILASSKG DHLTTIFYYCRSIAVKFPFP AASTNLQKALSKALESRDE |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SMG7 (NP_963863.2). |
Additional Info
| Function | Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. |
| Protein Name | Nonsense-Mediated Mrna Decay Factor Smg7Smg-7 HomologHsmg-7 |
| Database Links | Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicAnd NuclearShuttles Between Nucleus And Cytoplasm |
| Alternative Antibody Names | Anti-Nonsense-Mediated Mrna Decay Factor Smg7 antibodyAnti-Smg-7 Homolog antibodyAnti-Hsmg-7 antibodyAnti-SMG7 antibodyAnti-C1orf16 antibodyAnti-EST1C antibodyAnti-KIAA0250 antibody |
Information sourced from Uniprot.org