Anti-SMG6 antibody (688-738) (STJA0006521)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human EST1A AA range: 688-738
General Information
| Short Description | Rabbit polyclonal anti-Telomerase-binding protein EST1A (688-738) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SMG6 |
| Gene ID | 23293 |
| Uniprot ID | EST1A_HUMAN |
| Immunogen | Synthesized peptide derived from human EST1A AA range: 688-738 |
| Immunogen Region | 688-738 |
| Specificity | This antibody detects endogenous levels of human EST1A |
Additional Info
| Function | Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA. |
| Protein Name | Telomerase-Binding Protein Est1aEver Shorter Telomeres 1aHest1aNonsense Mediated Mrna Decay Factor Smg6Smg-6 HomologHsmg5/7a |
| Database Links | Reactome: R-HSA-975957 |
| Cellular Localisation | NucleusNucleolusChromosomeTelomereCytoplasmCytosolParticularly Enriched In The Nucleolus |
| Alternative Antibody Names | Anti-Telomerase-Binding Protein Est1a antibodyAnti-Ever Shorter Telomeres 1a antibodyAnti-Hest1a antibodyAnti-Nonsense Mediated Mrna Decay Factor Smg6 antibodyAnti-Smg-6 Homolog antibodyAnti-Hsmg5/7a antibodyAnti-SMG6 antibodyAnti-C17orf31 antibodyAnti-EST1A antibodyAnti-KIAA0732 antibody |
Information sourced from Uniprot.org