| Short Description : | Rabbit polyclonal SMG5 (950-1016) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SMG5 |
| Gene ID: | 23381 |
| Uniprot ID: | SMG5_HUMAN |
| Immunogen Region: | 950-1016 |
| Immunogen Sequence: | DSCKQLTLAQGAGEEDPSGM VTIITGLPLDNPSVLSGPMQ AALQAAAHASVDIKNVLDFY KQWKEIG |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 950-1016 of human SMG5 (NP_056142.2). |
| Tissue Specificity | Ubiquitous. |
| Function | Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. |
| Protein Name | Nonsense-Mediated Mrna Decay Factor Smg5Est1-Like Protein BLpts-Rp1Lpts-Interacting ProteinSmg-5 HomologHsmg-5 |
| Database Links | Reactome: R-HSA-975957 |
| Cellular Localisation | CytoplasmNucleusPredominantly CytoplasmicAnd NuclearShuttles Between Nucleus And CytoplasmDetected In Cytoplasmic Mrna Decay Bodies |
| Alternative Antibody Names | Anti-Nonsense-Mediated Mrna Decay Factor Smg5 antibodyAnti-Est1-Like Protein B antibodyAnti-Lpts-Rp1 antibodyAnti-Lpts-Interacting Protein antibodyAnti-Smg-5 Homolog antibodyAnti-Hsmg-5 antibodyAnti-SMG5 antibodyAnti-EST1B antibodyAnti-KIAA1089 antibody |
Information sourced from Uniprot.org
