Anti-SMDT1 antibody (9-59 aa) (STJ197967)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human CV032 at the amino acid range 9-59
General Information
| Short Description | Rabbit polyclonal anti-Essential MCU regulator, mitochondrial (9-59 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SMDT1 |
| Gene ID | 91689 |
| Uniprot ID | EMRE_HUMAN |
| Immunogen | Synthesized peptide derived from the human CV032 at the amino acid range 9-59 |
| Immunogen Region | 9-59 aa |
| Specificity | This antibody detects endogenous levels of human CV032 |
Additional Info
| Function | Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria. Required to bridge the calcium-sensing proteins MICU1 with the calcium-conducting subunit MCU. Acts by mediating activation of MCU and retention of MICU1 to the MCU pore, in order to ensure tight regulation of the uniplex complex and appropriate responses to intracellular calcium signaling. |
| Protein Name | Essential Mcu Regulator - MitochondrialSingle-Pass Membrane Protein With Aspartate-Rich Tail 1 - Mitochondrial |
| Database Links | Reactome: R-HSA-8949215Reactome: R-HSA-8949664Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane ProteinMaip1 Is Required To Assist Sorting Of Emre/Smdt1 Into Mitochondrion By Protecting Emre/Smdt1 Against Protein Degradation By Yme1l1Thereby Ensuring Smdt1/Emre Maturation By The Mitochondrial Processing Peptidase (Pmpca And Pmpcb) |
| Alternative Antibody Names | Anti-Essential Mcu Regulator - Mitochondrial antibodyAnti-Single-Pass Membrane Protein With Aspartate-Rich Tail 1 - Mitochondrial antibodyAnti-SMDT1 antibodyAnti-C22orf32 antibodyAnti-EMRE antibody |
Information sourced from Uniprot.org