Anti-SMCHD1 antibody (1480-1530 aa) (STJ196126)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SMHD1 at the amino acid range 1480-1530
General Information
| Short Description | Rabbit polyclonal anti-Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (1480-1530 aa) for use in WB and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SMCHD1 |
| Gene ID | 23347 |
| Uniprot ID | SMHD1_HUMAN |
| Immunogen | Synthesized peptide derived from the human SMHD1 at the amino acid range 1480-1530 |
| Immunogen Region | 1480-1530 aa |
| Specificity | This antibody detects endogenous levels of SMHD1 at Human/Mouse |
Additional Info
| Function | Non-canonical member of the structural maintenance of chromosomes (SMC) protein family that plays a key role in epigenetic silencing by regulating chromatin architecture. Promotes heterochromatin formation in both autosomes and chromosome X, probably by mediating the merge of chromatin compartments. Plays a key role in chromosome X inactivation in females by promoting the spreading of heterochromatin. Recruited to inactivated chromosome X by Xist RNA and acts by mediating the merge of chromatin compartments: promotes random chromatin interactions that span the boundaries of existing structures, leading to create a compartment-less architecture typical of inactivated chromosome X. Required to facilitate Xist RNA spreading. Also required for silencing of a subset of clustered autosomal loci in somatic cells, such as the DUX4 locus. Has ATPase activity.may participate in structural manipulation of chromatin in an ATP-dependent manner as part of its role in gene expression regulation. Also plays a role in DNA repair: localizes to sites of DNA double-strand breaks in response to DNA damage to promote the repair of DNA double-strand breaks. Acts by promoting non-homologous end joining (NHEJ) and inhibiting homologous recombination (HR) repair. |
| Protein Name | Structural Maintenance Of Chromosomes Flexible Hinge Domain-Containing Protein 1Smc Hinge Domain-Containing Protein 1 |
| Database Links | |
| Cellular Localisation | ChromosomeRecruited To Inactivated Chromosome X In Females By Xist RnaLocalizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Antibody Names | Anti-Structural Maintenance Of Chromosomes Flexible Hinge Domain-Containing Protein 1 antibodyAnti-Smc Hinge Domain-Containing Protein 1 antibodyAnti-SMCHD1 antibodyAnti-KIAA0650 antibody |
Information sourced from Uniprot.org