| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SMC5 (872-1101) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:3000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SMC5 |
| Gene ID: |
23137 |
| Uniprot ID: |
SMC5_HUMAN |
| Immunogen Region: |
872-1101 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 872-1101 of human SMC5 (NP_055925.2). |
| Immunogen Sequence: |
LTEERSRASCFTGLNPTIVQ EYTKREEEIEQLTEELKGKK VELDQYRENISQVKERWLNP LKELVEKINEKFSNFFSSMQ CAGEVDLHTENEEDYDKYGI RIRVKFRSSTQLHELTPHHQ SGGERSVSTMLYLMALQELN RCPFRVVDEINQGMDPINER RVFEMVVNTACKENTSQYFF ITPKLLQNLPYSEKMTVLFV YNGPHMLEPNTWNLKAFQRR RRRITFTQPS |
| Tissue Specificity | Widely expressed. Strongly expressed in testis. |
| Post Translational Modifications | Sumoylated. Ubiquitinated. (Microbial infection) SMC5-SMC6 complex is degraded by the activity of Hepatitis B X protein. |
| Function | Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression.the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome. |
| Protein Name | Structural Maintenance Of Chromosomes Protein 5Smc Protein 5Smc-5Hsmc5 |
| Database Links | Reactome: R-HSA-3108214 |
| Cellular Localisation | NucleusChromosomePml BodyTelomereAssociates With ChromatinColocalizes With Smc6 On The X-Y Chromosome Pair Within The Sex Vesicle During Late Pachytene/DiploteneLocalizes To Pml Nuclear Bodies In Alt Cell LinesAccumulates With Rad18 And The Slf1-Slf2 Complex At Replication-Coupled Dna Interstrand Repair And Dna Double-Strand Breaks (Dsbs) Sites On Chromatin In A Ubiquitin-Dependent Manner |
| Alternative Antibody Names | Anti-Structural Maintenance Of Chromosomes Protein 5 antibodyAnti-Smc Protein 5 antibodyAnti-Smc-5 antibodyAnti-Hsmc5 antibodyAnti-SMC5 antibodyAnti-KIAA0594 antibodyAnti-SMC5L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
