| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SMC4 (1-100) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SMC4 |
| Gene ID: |
10051 |
| Uniprot ID: |
SMC4_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMC4 (NP_001275682.1). |
| Immunogen Sequence: |
MPRKGTQPSTARRREEGPPP PSPDGASSDAEPEPPSGRTE SPATAAAMTNEAGAPRLMIT HIVNQNFKSYAGEKILGPFH KRFSCIIGPNGSGKSNVIDS |
| Tissue Specificity | Widely expressed. Higher expression in testis, colon, thymus. |
| Function | Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. |
| Protein Name | Structural Maintenance Of Chromosomes Protein 4Smc Protein 4Smc-4Chromosome-Associated Polypeptide CHcap-CXcap-C Homolog |
| Database Links | Reactome: R-HSA-2299718Reactome: R-HSA-2514853 |
| Cellular Localisation | NucleusCytoplasmChromosomeIn Interphase CellsThe Majority Of The Condensin Complex Is Found In The CytoplasmWhile A Minority Of The Complex Is Associated With ChromatinA Subpopulation Of The Complex However Remains Associated With Chromosome Foci In Interphase CellsDuring MitosisMost Of The Condensin Complex Is Associated With The ChromatinAt The Onset Of ProphaseThe Regulatory Subunits Of The Complex Are Phosphorylated By Cdc2Leading To Condensin's Association With Chromosome Arms And To Chromosome CondensationDissociation From Chromosomes Is Observed In Late Telophase |
| Alternative Antibody Names | Anti-Structural Maintenance Of Chromosomes Protein 4 antibodyAnti-Smc Protein 4 antibodyAnti-Smc-4 antibodyAnti-Chromosome-Associated Polypeptide C antibodyAnti-Hcap-C antibodyAnti-Xcap-C Homolog antibodyAnti-SMC4 antibodyAnti-CAPC antibodyAnti-SMC4L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
