Anti-SMARCD2 antibody (454-531) (STJ113998)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SMARCD2 (454-531) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SMARCD2 |
| Gene ID | 6603 |
| Uniprot ID | SMRD2_HUMAN |
| Immunogen Region | 454-531 |
| Immunogen Sequence | RDFMLSFSTDPQDFIQEWLR SQRRDLKIITDVIGNPEEER RAAFYHQPWAQEAVGRHIFA KVQQRRQELEQVLGIRLT |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 454-531 of human SMARCD2 (NP_001091896.1). |
Additional Info
| Tissue Specificity | Isoform 2 is expressed in the pancreas. |
| Post Translational Modifications | Ubiquitinated through a signaling process involving RAC1 and the RING finger protein UNKL. |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Critical regulator of myeloid differentiation, controlling granulocytopoiesis and the expression of genes involved in neutrophil granule formation. |
| Protein Name | Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily D Member 260 Kda Brg-1/Brm-Associated Factor Subunit BBrg1-Associated Factor 60bBaf60b |
| Database Links | Reactome: R-HSA-3214858Reactome: R-HSA-8939243Reactome: R-HSA-9824585Reactome: R-HSA-9845323 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily D Member 2 antibodyAnti-60 Kda Brg-1/Brm-Associated Factor Subunit B antibodyAnti-Brg1-Associated Factor 60b antibodyAnti-Baf60b antibodyAnti-SMARCD2 antibodyAnti-BAF60B antibodyAnti-PRO2451 antibody |
Information sourced from Uniprot.org