• Human epithelioid sarcoma stained with anti-INI-1 antibody using peroxidase-conjugate and DAB. Note the absence of nuclear staining of stromal/endothelial cells and absence of staining in tumor cells, whereas the background cells with nuclear staining.

Anti-SMARCB1 antibody (257-359aa) [25] (STJ180136)

SKU:
STJ180136

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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-SMARCB1 (257-359aa) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 25
Conjugation: Unconjugated
Isotype: IgG2a/Kappa
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:50‐100
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol: SMARCB1
Gene ID: 6598
Uniprot ID: SNF5_HUMAN
Immunogen Region: 257-359aa
Specificity: Positive control: Brain or astrocytoma
Immunogen: Mouse BAF47 aa 257-359
Function Core component of the BAF (hSWI/SNF) complex. This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. Plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1.
Protein Name Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily B Member 1
Brg1-Associated Factor 47
Baf47
Integrase Interactor 1 Protein
Snf5 Homolog
Hsnf5
Database Links Reactome: R-HSA-3214858
Reactome: R-HSA-8939243
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Swi/Snf-Related Matrix-Associated Actin-Dependent Regulator Of Chromatin Subfamily B Member 1 antibody
Anti-Brg1-Associated Factor 47 antibody
Anti-Baf47 antibody
Anti-Integrase Interactor 1 Protein antibody
Anti-Snf5 Homolog antibody
Anti-Hsnf5 antibody
Anti-SMARCB1 antibody
Anti-BAF47 antibody
Anti-INI1 antibody
Anti-SNF5L1 antibody

Information sourced from Uniprot.org

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