Anti-SLFN12 antibody (320-390) (STJ11103197)

Name: Anti-SLFN12 antibody (320-390) (STJ11103197)
SKU: STJ11103197
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11103197

Current Stock:

🚚 Free UK Delivery on orders over £150

Quantity:

Processing The item has been added

Enquire For Bulk Order

✓ 1-Year Performance Guarantee | SDS & Datasheet Included | Expert Tech Support | Covered by St John's Laboratory Guarantee

Short Description	Rabbit polyclonal SLFN12 (320-390) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	SLFN12
Gene ID	55106
Uniprot ID	SLN12_HUMAN
Immunogen Region	320-390
Immunogen Sequence	DSWHVKDNRVMQLTRKEWIQ FMVEAEPKFSSSYEEVISQI NTSLPAPHSWPLLEWQRQRH HCPGLSGRITY
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 320-390 of human SLFN12 (NP_001275938.1).

Post Translational Modifications	Phosphorylation at Ser-368 and Ser-573 negatively regulates the ribonuclease activity. Dephosphorylation is induced by the interaction with PDE3A and stimulates the rRNA ribonuclease activity.
Function	Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. May play a role in cell differentiation.
Protein Name	Ribonuclease Slfn12 Schlafen Family Member 12
Database Links
Cellular Localisation	Nucleus Cytoplasm Cytosol
Alternative Antibody Names	Anti-Ribonuclease Slfn12 antibody Anti-Schlafen Family Member 12 antibody Anti-SLFN12 antibody

Information sourced from Uniprot.org