Anti-SLFN11 antibody (132-328) [S7MR] (STJ11103467)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal SLFN11 (132-328) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S7MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLFN11 |
| Gene ID | 91607 |
| Uniprot ID | SLN11_HUMAN |
| Immunogen Region | 132-328 |
| Immunogen Sequence | LYRRSETSVRSMDSREAFCF LKTKRKPKILEEGPFHKIHK GVYQELPNSDPADPNSDPAD LIFQKDYLEYGEILPFPESQ LVEFKQFSTKHFQEYVKRTI PEYVPAFANTGGGYLFIGVD DKSREVLGCAKENVDPDSLR RKIEQAIYKLPCVHFCQPQR PITFTLKIVNVLKRGELYGY ACMIRVNPFCCAVFSEA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 132-328 of human SLFN11 (NP_689483.3). |
Additional Info
| Tissue Specificity | Exhibits a wider expression range in ovarian and colon adenocarcinoma than in their corresponding healthy tissues. |
| Function | Inhibitor of DNA replication that promotes cell death in response to DNA damage. Acts as a guardian of the genome by killing cells with defective replication. Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death. Upon DNA damage, inhibits translation of ATR or ATM based on distinct codon usage without disrupting early DNA damage response signaling. Antiviral restriction factor with manganese-dependent type II tRNA endoribonuclease. A single tRNA molecule is bound and cleaved by the SLFN11 dimer. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Impairs the replication of human cytomegalovirus (HCMV) and some Flaviviruses. Exploits the unique viral codon bias towards A/T nucleotides. Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. |
| Protein Name | Schlafen Family Member 11 |
| Database Links | |
| Cellular Localisation | NucleusChromosomeRecruited To Stressed Replication Forks Carrying Extended Rpa FilamentsRecruited To Dna Damage Sites Via Interaction With Rpa1 |
| Alternative Antibody Names | Anti-Schlafen Family Member 11 antibodyAnti-SLFN11 antibody |
Information sourced from Uniprot.org