Anti-SLC9A5 antibody (STJ191444)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Sodium/hydrogen exchanger 5/H+ exchanger 5 for use in WB and ELISA in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SLC9A5 |
| Gene ID | 6553 |
| Uniprot ID | SL9A5_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SL9A5 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated by PRKAA2.promotes its accumulation at the cell surface. Phosphorylated by CSNK2A1 in a manner favoring its beta-arrestin binding and endocytosis. |
| Function | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues. Acts as a negative regulator of dendritic spine growth. Plays a role in postsynaptic remodeling and signaling. Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking. |
| Protein Name | Sodium/Hydrogen Exchanger 5Na(+/H(+ Exchanger 5Nhe-5Solute Carrier Family 9 Member 5 |
| Database Links | Reactome: R-HSA-425986 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneCell ProjectionDendritic Spine MembraneSynaptic Cell MembraneCell JunctionFocal AdhesionCycles Between Recycling Endosome And Plasma Membrane In Response To Diverse StimuliIts Internalization Is Clathrin- And Beta-Arrestin Dependent And Its Plasma Membrane Insertion From The Recycling Endosomes Requires Phosphoinositide 3-Kinase (Pik3ca) And Scamp2 |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 5 antibodyAnti-Na(+/H(+ Exchanger 5 antibodyAnti-Nhe-5 antibodyAnti-Solute Carrier Family 9 Member 5 antibodyAnti-SLC9A5 antibodyAnti-NHE5 antibody |
Information sourced from Uniprot.org