Anti-SLC9A5 antibody (C-Term) (STJ13102118)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from c-terminal region of human SLC9A5 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
General Information
| Short Description | Rabbit polyclonal anti-SLC9A5 (C-Term) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SLC9A5 |
| Gene ID | 6553 |
| Uniprot ID | SL9A5_HUMAN |
| Immunogen | A synthetic peptide from c-terminal region of human SLC9A5 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Immunogen Region | C-Term |
| Specificity | Specific for SLC9A5. |
Additional Info
| Post Translational Modifications | Phosphorylated by PRKAA2.promotes its accumulation at the cell surface. Phosphorylated by CSNK2A1 in a manner favoring its beta-arrestin binding and endocytosis. |
| Function | Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues. Acts as a negative regulator of dendritic spine growth. Plays a role in postsynaptic remodeling and signaling. Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking. |
| Protein Name | Sodium/Hydrogen Exchanger 5Na(+/H(+ Exchanger 5Nhe-5Solute Carrier Family 9 Member 5 |
| Database Links | Reactome: R-HSA-425986 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinRecycling Endosome MembraneCell ProjectionDendritic Spine MembraneSynaptic Cell MembraneCell JunctionFocal AdhesionCycles Between Recycling Endosome And Plasma Membrane In Response To Diverse StimuliIts Internalization Is Clathrin- And Beta-Arrestin Dependent And Its Plasma Membrane Insertion From The Recycling Endosomes Requires Phosphoinositide 3-Kinase (Pik3ca) And Scamp2 |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 5 antibodyAnti-Na(+/H(+ Exchanger 5 antibodyAnti-Nhe-5 antibodyAnti-Solute Carrier Family 9 Member 5 antibodyAnti-SLC9A5 antibodyAnti-NHE5 antibody |
Information sourced from Uniprot.org