Anti-SLC9A1 antibody (700-750) {FITC} (STJ501920)

SKU:
STJ501920-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SLC9A1 (700-750) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:150
ICC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SLC9A1
Gene ID: 6548
Uniprot ID: SL9A1_HUMAN
Immunogen Region: 700-750
Immunogen: Synthetic peptide taken within amino acid region 700-750 on human Sodium/hydrogen exchanger 1/SLC9A1 protein.
Tissue Specificity Kidney and intestine.
Post Translational Modifications O-glycosylated. Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is reduced by CHP1. Phosphorylation at Thr-779 increases SLC9A1 activity. Specifically dephosphorylated at Thr-779 by PPP3CA that negatively regulates SLC9A1 activity. Phosphorylation at Ser-648 by AKT1 reduces SLC9A1 binding to CALM1. Palmitoylated.may play a major role in SLC9A1 regulation.
Function Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry. Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and functions also as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs.
Protein Name Sodium/Hydrogen Exchanger 1
Apnh
Na(+/H(+ Antiporter - Amiloride-Sensitive
Na(+/H(+ Exchanger 1
Nhe-1
Solute Carrier Family 9 Member 1
Database Links Reactome: R-HSA-2160916
Reactome: R-HSA-425986
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Basolateral Cell Membrane
Localized Basolaterally In Every Epithelial Cell
Except In The Choroid Plexus Where Slc9a1 Is Expressed Luminally
Alternative Antibody Names Anti-Sodium/Hydrogen Exchanger 1 antibody
Anti-Apnh antibody
Anti-Na(+/H(+ Antiporter - Amiloride-Sensitive antibody
Anti-Na(+/H(+ Exchanger 1 antibody
Anti-Nhe-1 antibody
Anti-Solute Carrier Family 9 Member 1 antibody
Anti-SLC9A1 antibody
Anti-APNH1 antibody
Anti-NHE1 antibody

Information sourced from Uniprot.org

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